Welcome to the MEPIS Forums!
When you make a post like that, you've gotta learn to tell us
what VERSION (of Wine, in this case) you are running!
There was some discussion of similar problems on Wine,
back a few months ago. Some of us had better
luck using a much older version of Wine (i.e. 1.0.1)
rather than some of the newer. Details on that thread is here:http://mepislovers.org/forums/showthread.php?t=18149
Look at some of the last replies on that thread.
That said, when I more recently installed the 1.1.35 version posted here:http://mepislovers.org/forums/showthread.php?t=24310
it seems to fix most of the issues that I was having with
games under Wine.
As usual, your mileage may vary.