Re: Synaptic Did Not Load >> HELP
One of the error messages in your first post shows that you have a sid repo enabled
Mepis is based on Debian stable (in the case of Mepis 11.0 Debian stable is codenamed Squeeze). Sid is unstable and is the repo which most newer version packages come from, but it can be kind of dangerous to mix sid/unstable repos with stable repos. I'm guessing the sid repo might have been added (by you, or your son) with the thought that you would be able to get a more recent version of Wine. Adding the sid repo is also what probably caused the cache to exceed it's limit.
You can disable the sid repo in Synaptic by going to Settings -> Repositories. Scroll thru the repo entries to find the one for the sid repo.
Section(s): main contrib non-free
Your entry might not be exactly as shown above, the main thing you're looking for is an entry with "sid" in the Distribution field. Clear the checkbox for that repo entry, press the 'OK' button to save the changes, and then press the 'Reload' button.